An auditory display tool for DNA sequence analysis
Select an algorithm
Reading frame codon options
Play START with Snare drum and STOP with Crash Cymbal
The Reading-frame-codons algorithm sonifys each overlapping codon (made up of 3 base) as a single note. Codons in 3 reading frames are sonified using 3 instruments. A start codon is ATG and there are 3 stop codons (TGA, TAG and TAA). These codons act to start or stop protein synthesis. The Protein-sequence algorithm plays only the open reading frame (assume reading frame 1) and non-overlapping codons are mapped to 20 notes, since there are 20 different amino acid residues in a protein. The Tri-nucleotides algorithms plays all codons (64 in total) as individual notes. The two Di-nucleotide algorithms sonify overlapping or non-overlapping motifs of 2 base-pairs. Overlapping motifs are sonified using 2 instruments and only 16 notes are possible. Lastly the Mono-nucleotides algorithm sonifies each individual bases to a single note.
Options only apply to the
With the Silent-until-ATG option, no audio is generated in either frame until an ATG codon is detected, often this causes the sonification to be silent at the begining. The Restart-on-ATG option plays all codons from the beginning of the sequence. For both of these options, a Stop codon will silence the audio in the frame in which it occurs (this effects only one instrument). The Restart-after-10-codons option automatically turns the audio on again in the absence of a Start codon - simply to avoid long periods of silence. Each frames is audible until a STOP codon occurs, ATG restarts the frames audio. The Ignore-Start/Stop option will play all codons for the entire sequence.
Apply the Sonification Algorithm above to the chosen DNA sequence below. This will create an auditory display so that you can hear the sequence.